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KMID : 0829220090330060347
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Korean Journal of Oral and Maxillofacial Pathology
2009 Volume.33 No. 6 p.347 ~ p.352
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The Effect of Cyclosporine A on The Proliferation and Differentiation of SGT Cell Line
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Lee Chong-Heon
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Abstract
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Cyclosporine A (Cs A) which is a highly lipophilic cyclic undecapeptide mainly used for its immunosuppressive properties exert a wide spectrum of biological activities including fungicidal antiproliferactive, anti-inflammatory and chemotherapuetic effects. Human salivary gland adenocarcinoma is very aggressive characteristics, which is need to get the effective chemotherapuetic methods. Subconfluent SGT cell cultures have been treated with CsA at in vivo relevant concentrations for 24h. MTT assay for cellular proliferation of cultured SGT cell line has been performed and TGase 1 activity assay for cellular differentiation has been detected in the CsA-treated samples. It suggested that CsA could have an inhibitory effect in the proliferation of SGT cell line but no in the differentiation.
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KEYWORD
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Cyclosporine A, Proliferation, Differentiation, SGT Cell Line
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